Multi-omics Characterization and Model Construction of Colchicine Anti-inflammatory Therapy Efficacy in ACS Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorShanghai Tongji Hospital, Tongji University School of Medicine

About this trial

The aim of this prospective cohort study was to investigate the multi-omics characteristics of the efficacy of colchicine treatment in patients with ACS and to construct a model of efficacy. The main questions the study aims to answer are

\- Specific mechanisms of colchicine therapy in patients with ACS; Mechanism-based modelling to identify the population that benefits from colchicine treatment.

Eligibility criteria

Qualifiers

Between the ages of 18 and 80

ACS (STEMI or NSTE-ACS)

Patients to receive standardised drug therapy

Able and willing to provide informed consent

Disqualifiers

Any contraindication to colchicine or known intolerance to colchicine

Has been using colchicine for a prolonged period of time for other medical conditions

Women of childbearing age who are pregnant, breastfeeding or not using effective contraception

Coronary artery bypass grafting within the last 3 years or planned

Trial design

Treatments tested in this trial

  • Colchicine 0.5 MG Oral Tablet Once Daily

Treatment groups

380 Participants
are divided into 2 treatment groups