Multi-parametric Imaging in Personalized Radiotherapy
ConditionSkull Base Chordoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCNAO National Center of Oncological Hadrontherapy
About this trial
The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.
Eligibility criteria
Qualifiers
Patients with histologically confirmed diagnosis of chordoma of the skull base
Particle therapy with curative intent
Karnofsky Performance status greater than or equal to 60
Patients with macroscopic disease detectable at pre-radiotherapy imaging
Disqualifiers
Metastatic disease
Palliative treatment
Other malignancies with disease-free interval < 5 years (excepting pre- cancerous lesions)
Pregnancy
Trial design
Treatments tested in this trial
- diffusion MRI sequences
Treatment groups
35 Participants
are divided into 2 treatment groupsSponsors and collaborators
CNAO National Center of Oncological Hadrontherapy
Lead sponsor
Dept. of Electronics, Informatics, Bioengineering, Politecnico di Milano, Italy
Collaborator
Source ClinicalTrials.gov