Multi-Parametric MRI for Renal Transplantation
ConditionRenal Transplant Rejection
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of Minnesota
About this trial
The goals of this study are:
* To optimize and evaluate multiple kidney MRI methods; and * To investigate the potential of MRI in the assessment of transplant kidney functions; To achieve these goals, we will perform pilot MRI studies with kidney transplant patients. We will study if MRI can reflect different levels of kidney function. The investigators will also evaluate if MRI can differentiate causes for declining kidney function. Finally, the investigators will explore how MRI measures changes before and after medical treatment for worsening kidney function.
You may be invited for MRI exams with different exam options. An MRI exam may use either of two types of MRI machines at the center for magnetic resonance research (CMRR): the 3 Tesla (3T) scanner and the 7 Tesla (7T) scanner. You may also be invited for a multi-session exam. A description of the MRI exam types with different exam options and the types of multi-session exams is provided later in this document.
Eligibility criteria
Qualifiers
Renal Transplant Recipients
Capable to consent
English speaking
For studies with patients with fast worsening renal function: An abrupt (within 48 h) reduction in kidney function currently defined as a percentage increase in serum creatinine of ≥50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria of less than 0.5 mL/kg/h for more than 6 h).
Disqualifiers
On dialysis due to renal allograft failure
Acute and chronic pulmonary disease
Pregnancy as reported in CMRR Safety Screen
Ferromagnetic implants
Trial design
Treatments tested in this trial
- Magnetic Resonance Imaging
Treatment groups
140 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov