Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorInstitute of Hematology & Blood Diseases Hospital, China

About this trial

To study the optimal therapeutic strategies for salvage treatment of refractory/relapsed AML, and to clarify the effectiveness and safety of various salvage treatment options. A prospective, multicenter, platform-type study was conducted to explore the overall response rate, tolerability, and survival of patients with R/R AML with different treatment regimens.

Eligibility criteria

Qualifiers

1. Patients with acute myeloid leukemia (except for acute promyelocytic leukemia) diagnosed by bone marrow cell morphology, immunology and genetics above are classified according to the French-British-American Collaboration diagnostic criteria (FAB criteria) and the World Health Organization diagnostic criteria (WHO2016 criteria).

Disqualifiers

Concurrent malignant tumors of other organs (patients requiring treatment).

Participants considered unsuitable for inclusion by the researchers.

Trial design

Treatments tested in this trial

  • Ivosidenib,Venetoclax,gilteritinib,Selinexor

Treatment groups

120 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.