Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-70
SponsorShanghai High Myopia Study Group
About this trial
The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are:
1. Does TMS treatment improve the visual function of participants? 2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision.
Participants will:
UndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests
Eligibility criteria
Qualifiers
between 45 and 70 years old
bilateral severe MMD (META-PM grades ≥ 3)
no prior TMS history or contraindications to TMS
Disqualifiers
other significant ocular diseases, such as refractive media opacity, glaucoma, uveitis, ocular trauma, untreated retinal detachment, or lens dislocation
received anti-vascular endothelial growth factor treatment or other ocular surgeries within 3 months
history of epilepsy or family history of epilepsy, intracranial metal implants, or severe cerebrovascular diseases
mental illness, cognitive impairment (MMSE score < 24), unable to communicate effectively
Trial design
Treatments tested in this trial
- Transcranial magnetic stimulation targeting occipital visual cortex
- Sham stimulation
Treatment groups
136 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov