Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.
Male or female aged 60 or above
Free of chronic disease
No structured exercise program (2 or more bouts/wk) within previous 12 months
Cognitively capable of providing informed consent
Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
Cardiopulmonary disorders or reduced breathing capacity
Metabolic diseases including markers of liver disease (ALT > 52 U/l) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)
Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
Florida Institute for Human and Machine Cognition
Lead sponsor
University of Florida
Collaborator
Oklahoma Medical Research Foundation
Collaborator