The goal of this study is improve the screening of heart failure and identify patients early who are at risk of heart failure.
The main question\[s\] it aims to answer are:
• will an electronic health records (EHR) case finding algorithm for heart failure, followed by N-Terminal pro-brain natriuretic peptide (NT-proBNP) screening and artificial intelligence (AI) echocardiogram compared to usual care identify patients at risk for heart failure earlier than standard of care?
Participants will be enrolled and randomized to either standard of care (SOC) or intervention arm:
SOC arm: electronic health records will be reviewed over six months for assessments performed to identify heart failure.
Intervention arm: blood sample for N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) at local laboratory . For elevated NT-proBNP results (\>125pg/ml) an artificial intelligence (AI) echocardiogram and 12 lead electrocardiogram (ECG) will be performed at study site (within 28 days of NT-proBNP result). EHR will be reviewed at six months
Male or female > 40 years of age
Informed consent
Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis or an epicardial coronary artery (50% left main stem or >70% left anterior descending, circumflex or right coronary artery)).
Diabetes type 1 or 2.
Inability to give informed consent (e.g. due to significant cognitive impairment).
Previous diagnosis of heart failure. This is any diagnosis of heart failure with any ejection fraction of any cause.
Renal replacement therapy.
Anyone who, in the investigator's opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period.
Cardiology Research UBC
Lead sponsor
AstraZeneca
Collaborator
Centre for Cardiovascular Innovation
Collaborator
NHS Greater Glasgow & Clyde
Collaborator
HeartLife Foundation
Collaborator
Canadian Heart Function Alliance
Collaborator
Montreal Heart Institute
Collaborator