Health Trials

Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

ConditionFollicular Lymphoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondazione Italiana Linfomi - ETS

About this trial

This is a Multicenter, Retrospective, Biological study ancillary to FOLL12 trial to evaluate the role of EZH2 aberrations in patient with FL treated with immunochemotherapy. Moreover, several novel biomarkers of FL will be investigated.

Eligibility criteria

Qualifiers

Patient enrolled in the FIL_FOLL12 trial (documented by the signature of the study informed consent);

Availability of biological samples: bone marrow aspirate, peripheral blood and/or FFPE diagnostic sample (nodal or extranodal);

Disqualifiers

None

Trial design

Treatments tested in this trial

  • EZH2 mutations/CNAs by droplet digital PCR (ddPCR)
  • EZH2-derived gene expression signature by RNA-Seq

Treatment groups

654 Participants
are divided into 1 treatment group

Sponsors and collaborators

Fondazione Italiana Linfomi - ETS

Lead sponsor

Source ClinicalTrials.gov