MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAnkara Etlik City Hospital

About this trial

In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.

Eligibility criteria

Qualifiers

Adults ≥18 years

Diagnosis of sepsis (per Sepsis-3 clinical criteria)

RRI measurement feasible at bedside

Informed consent from participant or legally authorized representative

Disqualifiers

End-stage kidney disease (chronic dialysis) or baseline eGFR <15mL/min/1.73 m²

Kidney transplant recipient

Anatomic/technical barrier precluding reliable renal Doppler (RRI) assessment

Pregnancy

Trial design

Treatments tested in this trial

  • Renal Resistive Index (RRI) Doppler Ultrasound
  • Urinary TIMP-2 and IGFBP-7 biomarkers

Treatment groups

130 Participants
are divided into 1 treatment group

Locations

This trial has no locations

Sponsors and collaborators