About this trial
In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.
Eligibility criteria
Qualifiers
Adults ≥18 years
Diagnosis of sepsis (per Sepsis-3 clinical criteria)
RRI measurement feasible at bedside
Informed consent from participant or legally authorized representative
Disqualifiers
End-stage kidney disease (chronic dialysis) or baseline eGFR <15mL/min/1.73 m²
Kidney transplant recipient
Anatomic/technical barrier precluding reliable renal Doppler (RRI) assessment
Pregnancy
Trial design
Treatments tested in this trial
- Renal Resistive Index (RRI) Doppler Ultrasound
- Urinary TIMP-2 and IGFBP-7 biomarkers