Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
The purpose of the bCAN study is to create a prospective collection of multimodal data and human samples, linked to the French Intracranial Aneurysm Registry (FRAN).
The aim of bCAN is to enable risk stratification of ruptured ICAs by redefining "intracranial aneurysm disease". The description of genotypically and phenotypically specific subgroups of cases will pave the way for improved patient management based on new diagnostic/prognostic strategies among AIC carriers, either in a familial context, or at the level of the general population.
Eligibility criteria
Qualifiers
Any adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography
Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available
Written consent obtained for study participation
Patient covered by a social security plan
Disqualifiers
Syndromic diagnosis known to cause ICA: Marfan syndrome, OSA with SMAD 3, Elhers Danlos syndrome type II and IV, Autosomal Dominant Cystic Fibrosis, Moya-Moya syndrome
AIC with : Dissecting or fusiform, Associated with arteriovenous malformation, Blister-like, Mycotic
Cerebral white matter pathology detected on MRI evoking : Col4a1 mutation
Patient under guardianship or conservatorship
Trial design
Treatments tested in this trial
- blood or saliva sample
Treatment groups
1,100 Participants
are divided into 1 treatment groupSponsors and collaborators
Nantes University Hospital
Lead sponsor
Federation of Medical Specialties
Collaborator
Source ClinicalTrials.gov