MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.
are aged 18-80;
have a documented diagnosis of PTSD with evidence of ongoing symptoms as demonstrated by score of "31" or higher on the PCL-5, a measure of posttraumatic stress symptoms;
are fluent in English (as the neuropsychological testing tools used are only available in English) and
have been on stable doses of psychotropic medications for the past month.
a prior history of other neurological disease beyond mild TBI, as determined by VA/DoD criteria for TBI severity;
any history of seizures beyond immediate posttraumatic seizure or childhood febrile seizure, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;
history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation;
active substance/alcohol dependence without ongoing treatment, to reduce confounding effects on diagnosis and brain imaging;
University of New Mexico
Lead sponsor
New Mexico VA Healthcare System
Collaborator