The primary objective of this study is to evaluate the vulnerability of intracranial and extracranial atherosclerotic plaques using HR-VWI, OCT, and RWS technologies, while exploring correlations among these three imaging techniques. Secondary objectives include: 1) Investigating the relationship between RWS and plaque progression and identifying optimal RWS predictors; 2) Further evaluating the clinical value of RWS and HR-VWI in stroke prediction through two-year clinical and HR-VWI follow-up evaluations.
At least 18 years old;
Severe stenosis of intracranial arteries (stenosis degree: 70% ~ 99%, traditional angiography is required to confirm the degree of stenosis according to the criteria of Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study);
Carry out cerebral angiography and OCT within one week after HR-VWI examination;
The patient or the legal representative of the patient is able and willing to sign an informed consent form.
Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;
There are contraindications to MRI, such as claustrophobia, metal implants, etc.; Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);
Patients with severe cardiopulmonary diseases were considered unsuitable for this study;
Allergy to iodine or gadolinium contrast agent;