About this trial
This is a Stage I randomized, sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging. Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of brain stimulation, with multimodal musical stimulation and control stimulation conditions. Results will test the causal role of oscillatory mechanisms of the brain on cognition, and will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.
Eligibility criteria
Qualifiers
normal or corrected-to-normal vision
no more than mild hearing loss
no recent history of neurological or psychiatric disorders, including mood disorders or use of medications that may affect cognition or responsiveness to music.
Disqualifiers
moderate or severe hearing loss (40+ dB)
visual impairment (including color blindness) that cannot be corrected with glasses or contacts
recently changed dosage of cholinesterase inhibitors or psychotropic medication
recent history of psychotic or schizophrenic episodes
Trial design
Treatments tested in this trial
- Gamma
- Synchrony