The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \[oral anticoagulation\], antiplatelet \[APT\]) and left atrial appendage closure \[LAAC\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multimodal assessment from combined brain and cardiologic work-up, and to optimize secondary prevention.
Age > 18 years old；
Acute ischemic stroke with onset ≤ 14 days；
Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation;
Informed consent obtained from the patient or his/her legal representative；
Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor;
Left atrial appendage has been removed or post occlusion device implantation;
Transient AF secondary to other reversible disorders；
Life expectancy less than 1 year;