Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorJakub Antczak
About this trial
Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.
Eligibility criteria
Qualifiers
severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion
Hamilton Depression Rating Scale between between 20 and 35 points at inclusion
The score in the Athens Insomnia Scale eight or more
The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2
Disqualifiers
Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy
Psychotic symptoms at the time of inclusion
Suicidal ideations and/or attempts within three months prior to inclusion
Trial design
Treatments tested in this trial
- Active rTMS over the left DLPFC and over the left DMPFC
- Active rTMS over the left DLPFC
- Sham rTMS
Treatment groups
90 Participants
are divided into 3 treatment groupsSponsors and collaborators
Jakub Antczak
Lead sponsor
Jagiellonian University
Sponsor institution
Andrzej Frycz Modrzewski Krakow University
Collaborator
Source ClinicalTrials.gov