Muscle Aging Phenotypes in Childhood Cancer Survivors
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSt. Jude Children's Research Hospital
About this trial
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distinct muscle health endotypes in adult survivors of childhood cancer using advanced imaging, neuromuscular testing, and functional assessment. Survivors with reduced muscle health and community controls will undergo multimodal magnetic resonance imaging and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing during a single study visit integrated into an ongoing cohort evaluation. Identifying mechanistic endotypes of impaired muscle health will support development of targeted interventions to preserve function and improve long-term outcomes in childhood cancer survivors.
Primary Objective:
\- Characterize reduced muscle health endotypes in childhood cancer survivors.
Secondary Objective:
\- Identify specific treatment and lifestyle related risk factors for each reduced muscle health endotype.
Exploratory Objective:
\- Host germline genetics will be associated with specific muscle endotypes.
Eligibility criteria
Qualifiers
Age 18 years old or older at time of consent and enrolled in SJLIFE.
Group 1: No cancer history
Group 2: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of <-0.5 AND exposure to a peripheral neurotoxin.
Group 3: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of <-0.5 AND NOT exposed to a peripheral neurotoxin.
Disqualifiers
Presence of implanted medical devices or metal that would interfere with MRI or MRS.
Female Participant is pregnant.
Body weight exceeding 300 pounds, due to MRI restrictions.
Inability to lie flat on his/her back for 90 minutes or longer for MRI.
Trial design
Treatments tested in this trial
- Multimodal Muscle Imaging and Functional Assessment
- Multimodal Muscle Imaging and Neuromuscular Assessment
- Comprehensive Muscle Phenotyping
- Integrated Neuromuscular and Imaging Evaluation
Treatment groups
533 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov