About this trial
Achilles tendinopathy is a frequent overuse disorder caused by repetitive loading of the tendon, particularly observed in athletes and middle-aged men. It is typically characterized by mid-portion pain, stiffness in the morning, and functional limitations, with structural alterations such as thickening and disrupted collagen alignment. Chronic progression often compromises performance and quality of life.
Eccentric training protocols, such as the Alfredson regimen, are commonly prescribed but their standardized nature does not fully address individual variability. Alternative approaches including Heavy Slow Resistance training and progressive loading models (e.g., Silbernagel protocol) have demonstrated clinical effectiveness and higher patient adherence, yet they still apply uniform loading across the triceps surae without accounting for architectural differences.
Given the heterogeneous structure of the soleus and gastrocnemii, targeted loading strategies may be required to optimize tendon adaptation. To address this, the present study employs a muscle architecture-based exercise program tailored to the functional and structural properties of each muscle. Ultrasound imaging will be used to evaluate muscle-tendon morphology, while isokinetic dynamometry and functional performance tests will quantify outcomes. Pain (VAS) and functional capacity (VISA-A) will also be assessed.
This randomized controlled trial aims to compare the effectiveness of an architecture-specific program with the Alfredson protocol on tendon remodeling, strength, endurance, functional performance, and symptom reduction in individuals with non-insertional Achilles tendinopathy.
Eligibility criteria
Qualifiers
Presence of pain and tenderness in the mid-portion of the Achilles tendon (2-6 cm proximal to the insertion) persisting for at least 3 months
Clinical diagnosis of non-insertional Achilles tendinopathy
Pain aggravated by physical activity
Palpable tenderness localized to the mid-portion of the tendon
Disqualifiers
Diagnosis of insertional Achilles tendinopathy
History of surgery or fracture in the affected lower limb within the past 12 months
Corticosteroid injection to the Achilles tendon within the past month
Presence of systemic diseases (e.g., diabetes mellitus, rheumatoid arthritis)
Trial design
Treatments tested in this trial
- Muscle Architecture-Based Exercise Program
- Alfredson Protocol
Treatment groups
Sponsors and collaborators
Halic University
Lead sponsor
Istanbul University
Collaborator