Muscle Vibration as a Countermeasure Against Hypoactivity-induced
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-45
SponsorCentre Hospitalier Universitaire de Saint Etienne
About this trial
Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.
Eligibility criteria
Qualifiers
Men and women.
Aged 18 to 45 years.
Body Mass Index (BMI) between 18,5 and 24,9 kg/m².
Engaging in at least 1.5 hours per week of physical activity (e.g., brisk walking, running, swimming, cycling).
Disqualifiers
Chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory disorders.
Personal history and/or risk factors for thrombosis.
Use of antidepressant medications.
Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study.
Trial design
Treatments tested in this trial
- Focal muscle vibration
- NO Focal muscle vibration
Treatment groups
42 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov