National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

ConditionsCardiomyopathy, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy Restrictive Arrhythmogenic Right Ventricular Dysplasia Non-Compaction Cardiomyopathy Familial Hypercholesterolemia Marfan Syndrome Ehlers-Danlos Syndrome, Vascular Type Loeys-Dietz Syndrome Long QT Syndrome Short Qt Syndrome Brugada Syndrome Catecholaminergic Polymorphic Ventricular Tachycardia Sudden Cardiac Death

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

AgeNot listed

SponsorHospital do Coracao

About this trial

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are:

Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Eligibility criteria

Qualifiers

Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines

Agree to receive genetic counseling

Sign informed consent form

Provide the information required in the case report form

Disqualifiers

Signature absent from informed consent form

Inadequate buccal swab (sample may be collected twice)

Trial design

Treatments tested in this trial

whole genome sequencing

Treatment groups

No treatment groups listed

Locations27

Select a site below to view it on the map.

Sponsors and collaborators

Hospital do Coracao

Lead sponsor

Instituto Nacional de Cardiologia de Laranjeiras

Collaborator

Universidade Federal do Rio de Janeiro

Collaborator

Source ClinicalTrials.gov