Natriuresis-guided Depletion After Cardiac Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens
About this trial
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients
Our goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.
Eligibility criteria
Qualifiers
Adult patient (age > 18 years)
Scheduled for cardiac surgery, including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures
Undergoing surgery with cardiopulmonary bypass (CPB)
Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery, as prescribed by the referring physician
Disqualifiers
Aortic arch repair requiring deep hypothermic circulatory arrest
Active endocarditis
Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)
Failure to wean from CPB requiring mechanical circulatory support
Trial design
Treatments tested in this trial
- Furosemide intravenous titration based on natriuresis
- Furosemide intravenous titration based on clinical examination
Treatment groups
102 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov