About this trial
Half of patients with lung cancer face a limited life span of one-year survival, which is characterized by severe physical and psychological symptoms. Differences in stage, comorbidity but also treatment may explain a large proportion of the social inequality in lung cancer survival. Some vulnerable patients may not receive first line treatment as planned either due to poor performance status or if they are not able to adhere to treatment appointments. Knowing how to navigate the health system may be a barrier preventing vulnerable patients in receiving optimal treatment. The primary aim of this randomised, controlled trial is to test whether a nurse-led individually tailored program including systematic screening of symptoms using PROs and a physical training program will significantly improve a composite outcome of survival and quality of life as the primary outcome among vulnerable lung cancer patients compared with standard care. Secondary outcomes include adherence to cancer treatment, symptom burden and overall survival.
Eligibility criteria
Qualifiers
Age ≥ 18 years of age
Diagnosed with NSCLC at all stages regardless of treatment intension at the participating departments
Performance status ≤ 2
Vulnerable according to pre-defined criteria
Disqualifiers
Severe untreated psychiatric disorder (e.g. psychosis) or cognitive problems (e.g. dementia) preventing informed consent
Not able to receive treatment
Not able to read and understand Danish -
Trial design
Treatments tested in this trial
- NAVIGATE
Treatment groups
Sponsors and collaborators
Zealand University Hospital
Lead sponsor
Danish Cancer Society
Collaborator
Odense University Hospital
Collaborator
Vejle Hospital
Collaborator
Hospital of Southern Jutland
Collaborator