For patients with locally advanced cholangiocarcinoma with resectable margins, patients who meet the selection criteria are randomly divided into two groups A and B. Group A: neoadjuvant PDT therapy combined with radical surgery; Group B: radical surgery. This study aims to explore the clinical effectiveness and safety of neoadjuvant photodynamic therapy for cholangiocarcinoma, as well as its role in destroying local tumors and enhancing systemic inflammation.
Patients with age between 18 to 75 years;
Patients'gender was not limited;
Patients with locally advanced cholangiocarcinoma who have a clear diagnosis of the primary disease and require surgical resection or potential surgical resection;
No history of radiotherapy and chemotherapy;
Women during pregnancy or breastfeeding, and those with mental illness;
Patients allergic to porphyrin drugs, porphyria;
Long-term use of glucocorticoids or autoimmune suppression;