Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-100
SponsorUniversity of California, Los Angeles

About this trial

The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.

Eligibility criteria

Qualifiers

Agreement to participate in the study

55-100 years of age

Right-handedness

In good general health

Disqualifiers

Unwilling or unable to provide informed consent

Diagnosis of dementia

Active major medical, psychiatric, or neurologic disorder associated with neurocognitive impairment

History of alcohol or substance abuse

Trial design

Treatments tested in this trial

  • Active Theta Burst Stimulation
  • Sham Theta Burst Stimulation

Treatment groups

70 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of California, Los Angeles

Lead sponsor

National Institute on Aging (NIA)

Collaborator