About this trial
The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are:
1. are there specific neural correlates for ageing effects on executive functioning (particularly inhibitory control) and decision-making? 2. Is there a relationship, at the behavioral and neural levels, between ageing-related changes in executive functioning and decision-making?
Healthy participants will be recruited for
1. a behavioral assessment including multiple tests of decision-making and executive functioning/inhibitory control; 2. a fMRI session to collect data concerning a) brain activity associated with decision-making and executive functioning, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging).
Results will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.
Eligibility criteria
Qualifiers
Healthy participants, as determined by screening assessments and principal investigator judgment
The participant must be able to comply with study requirements as judged by the principal investigator
Disqualifiers
Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow
Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility
Trial design
Treatments tested in this trial
- No intervention
Treatment groups
Sponsors and collaborators
Istituti Clinici Scientifici Maugeri SpA
Lead sponsor
Istituto Universitario di Studi Superiori Pavia
Collaborator