Neural Bases of Social Cognitive Processing in Healthy Individuals

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorIstituti Clinici Scientifici Maugeri SpA

About this trial

The goal of this single center non-interventional fMRI and EEG study is to assess the neural bases of social cognitive processing in healthy individuals, and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are:

* are there specific brain regions where individual differences in social cognitive performance reflect well-established metrics of social cogntion such as empathy and mentalizing? * is there a relationship, at the behavioral and neural levels, between ageing-related changes in social cognitive performance and empathy/mentalizing?

Healthy participants will be recruited for:

* a behavioral assessment including multiple tests of social cognition focused on empathy and mentalizing; * for half participants: a fMRI session to collect data concerning a) brain activity associated with action observation and social cognitive processing, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging) * for half participants: a EEG session to collect data concerning brain responsiveness to social cognitive processing with higher temporal resolution than that afforded by fMRI.

Results will provide an useful baseline for investigating alterations of social cognitive processing, and of their neural bases, in pathological conditions.

Eligibility criteria

Qualifiers

Healthy participants, as determined by screening assessments and principal investigator judgment

The participant must be able to comply with study requirements as judged by the principal investigator

Disqualifiers

Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse

Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow

Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility

Trial design

Treatments tested in this trial

  • No intervention

Treatment groups

200 Participants
are divided into 1 treatment group

Sponsors and collaborators

Istituti Clinici Scientifici Maugeri SpA

Lead sponsor

Istituto Universitario di Studi Superiori Pavia

Collaborator