About this trial
The goal of this single center non-interventional fMRI and EEG study is to assess the neural bases of social cognitive processing in healthy individuals, and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are:
* are there specific brain regions where individual differences in social cognitive performance reflect well-established metrics of social cogntion such as empathy and mentalizing? * is there a relationship, at the behavioral and neural levels, between ageing-related changes in social cognitive performance and empathy/mentalizing?
Healthy participants will be recruited for:
* a behavioral assessment including multiple tests of social cognition focused on empathy and mentalizing; * for half participants: a fMRI session to collect data concerning a) brain activity associated with action observation and social cognitive processing, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging) * for half participants: a EEG session to collect data concerning brain responsiveness to social cognitive processing with higher temporal resolution than that afforded by fMRI.
Results will provide an useful baseline for investigating alterations of social cognitive processing, and of their neural bases, in pathological conditions.
Eligibility criteria
Qualifiers
Healthy participants, as determined by screening assessments and principal investigator judgment
The participant must be able to comply with study requirements as judged by the principal investigator
Disqualifiers
Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow
Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility
Trial design
Treatments tested in this trial
- No intervention
Treatment groups
Sponsors and collaborators
Istituti Clinici Scientifici Maugeri SpA
Lead sponsor
Istituto Universitario di Studi Superiori Pavia
Collaborator