Neural Correlates of Stress and Perceived Control in Adolescent Depression
ConditionMajor Depressive Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age14-18
SponsorMclean Hospital
About this trial
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Eligibility criteria
Qualifiers
Inclusion Criteria: All Participants
Females of all ethnic origins See Section: Inclusion of Women and Minorities);
Ages 14-18 (See Section: Inclusion of Children);
Written informed assent/consent from adolescent and parent/guardian (if under age 18);
Disqualifiers
Exclusion Criteria: All Participants
History of head trauma with loss of consciousness;
History of seizure disorder;
Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease;
Trial design
Treatments tested in this trial
- Computer Task Manipulation
Treatment groups
80 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov