Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe Cleveland Clinic
About this trial
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.
Eligibility criteria
Qualifiers
Clinical diagnosis of Parkinson's disease
Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD
Clinically optimized DBS parameters for one month prior to enrollment
Ability to ambulate with or without an assistive device for 5 continuous minutes
Disqualifiers
Neurocognitive impairment that compromises the ability to provide informed consent
Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)
If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provided prior to participation.
Those who choose not to obtain physician clearance will not be eligible for participation. Those who do not receive physician clearance for high intensity exercise will not be eligible.
Trial design
Treatments tested in this trial
- Exercise
Treatment groups
36 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
The Cleveland Clinic
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov