Neural Mechanisms of Interpersonal Expectations on Negative Affect
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorTrustees of Dartmouth College
About this trial
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.
The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?
Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.
Eligibility criteria
Qualifiers
None
Disqualifiers
No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment
No self-reported current chronic pain, or acute pain within three months of the study period
No current migraine disorder (i.e., 15 headache days or more in 1 month)
Trial design
Treatments tested in this trial
- Session A: Positive Placebo + Active tTIS
- Session B: Positive Placebo + Sham tTIS
- Session C: Negative Placebo + Active tTIS
- Session D: Negative Placebo + Sham tTIS
- Session E: On-Placebo + Sham tTIS
- Session F: Off-Placebo + Sham tTIS
Treatment groups
196 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Source ClinicalTrials.gov