Neuraxial Labor Analgesia and Offspring Neurodevelopment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-35
SponsorDong-Xin Wang
About this trial
How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.
Eligibility criteria
Qualifiers
Primiparae between 18 and 35 years of age with term single cephalic pregnancy;
Undergo regular prenatal examination in the study centers;
Preparing to deliver vaginally.
Disqualifiers
History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);
History of diseases involving the hypothalamic-pituitary-adrenal axis;
Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.
Presence of contraindications to vaginal delivery;
Trial design
Treatments tested in this trial
- Neuraxial labor analgesia
- No neuraxial labor analgesia
Treatment groups
4,645 Participants
are divided into 2 treatment groupsSponsors and collaborators
Dong-Xin Wang
Lead sponsor
Peking University First Hospital
Sponsor institution
Shenzhen Maternity & Child Healthcare Hospital
Collaborator
Source ClinicalTrials.gov