Neurofeedback Intervention for Reading Deficits in Subacute Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorKessler Foundation
About this trial
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
Eligibility criteria
Qualifiers
First-ever left-hemisphere stroke < 3 months prior to study recruitment or healthy volunteer
Age: 18 - 80 years old
Fluent and literate in English prior to stroke
Reading deficits, defined as >3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.
Disqualifiers
Inability to consent or complete study tasks
Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)
A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)
Trial design
Treatments tested in this trial
- Motor Imagery and Real-Time fMRI Neurofeedback
- Motor Imagery and Sham fMRI Neurofeedback
Treatment groups
28 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov