Neurological Impact of Weight Reduction and Fitness Interventions
ConditionObesity and Overweight
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity of Sydney
About this trial
This study will test how significant weight loss through bariatric surgery, combined with a personalised exercise program, affects brain inflammation. Th investigators want to understand the connection between obesity-related body inflammation, metabolic issues, and brain inflammation and function.
Eligibility criteria
Qualifiers
18-80 years of age.
Eligible for bariatric surgery.
Willingness to provide informed consent and willingness to participate and comply with the study requirements
Disqualifiers
Unable to undertake MRI due to size restrictions i.e., shoulder width more than 70 cm.
History or clinical manifestation of any other significant metabolic, hematologic, pulmonary, cardio- vascular, gastrointestinal, neurologic, immune, hepatic, renal, urologic, muscular, and joint disorders, or cancer that, in the opinion of the investigator, would make the candidate ineligible for the study. For example, significant joint pain could interfere with adherence to the exercise program.
Have objectively assessed cognitive impairment as assessed by the Montreal Cognitive Assessment (MoCA) i.e., total score less than 26.
Non-MRI-compatible implanted devices or implants.
Trial design
Treatments tested in this trial
- Exercise
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Charles Perkins Centre Clinic Status unavailable 2050, Royal Prince Alfred Hospital, New South Wales
Australia
AustraliaSponsors and collaborators
University of Sydney
Lead sponsor
Washington University School of Medicine
Collaborator
Sydney Local Health District
Collaborator
Northern Sydney Local Health District
Collaborator
Source ClinicalTrials.gov