About this trial
Dentine hypersensitivity (also known as sensitive teeth) is a common dental condition in which the dentine, a layer of sensitive hard tissue under the enamel of the teeth, becomes exposed making the teeth sensitive to stimuli, such as hot and cold. It poses a significant challenge for clinicians and affects patients' quality of life.
The overall aim of the study is to understand if a way of measuring brain activity (electroencephalography \[EEG\]) shows a response to tooth stimulation, and see how these responses may be different in patients with dentine sensitivity.
EEG records brain signals and can provide information about how the brain processes painful stimuli. EEG recording is a non-evasive and painless procedure. It involves using a cap with small sensors called electrodes to pick up brain signals. During the EEG assessment appointment, brain signals will be recorded throughout the duration when cold temperatures and short bursts of air are applied to the tooth. Brain signals recorded during tooth stimulation from participants with and without dentine sensitivity will then be compared to explore if there are any differences.
The investigators hope that EEG responses could be helpful to objectively assess dentine sensitivity, further the understanding of brain processing of dental pain, and allow the comparison of the effectiveness of different treatment options in the future.
This information may help to improve treatments and the quality of life for patients with dentine sensitivity and potentially other types of dental pain.
Eligibility criteria
Qualifiers
Adults 18 years and older;
Understands and is willing, able and likely to comply with all study procedures and restrictions;
Accepts the form of the study and signs a declaration of informed consent;
In good health (in the opinion of the clinical dental professional);
Disqualifiers
Adults currently using maxillary or mandibular orthodontic appliances;
Obvious signs of untreated caries, which in the opinion of the clinical dental professional, will affect the scientific validity of the study;
Periodontal pocket depth ≥4mm in the anterior upper or lower sextants;
Evidence of periodontitis.
Trial design
Treatments tested in this trial
- Recording of brain activity using electroencephalography (EEG)
Treatment groups
Sponsors and collaborators
Sheffield Teaching Hospitals NHS Foundation Trust
Lead sponsor
University of Sheffield
Collaborator
HALEON
Collaborator