Neuromodulation of Memory in Aging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorDuke University
About this trial
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.
Eligibility criteria
Qualifiers
English Speaking
Willing to provide consent
Disqualifiers
History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders
Current history of substance abuse or dependence (excluding nicotine)
Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device
Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Duke University
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov