Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Alabama at Birmingham

About this trial

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These movement disorders commonly have significant non-motor features, such as depression, cognitive and memory impairment, decreased attention, speech and language disturbances, and slower processing speeds. The investigators are interested in the brain activity associated with these motor and non-motor symptoms, and propose to investigate changes in brain activity while the investigators perform recordings of the surface and deep structures of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.

Eligibility criteria

Qualifiers

Eligible for DBS surgery based on multi-disciplinary consensus review

Have a diagnosis of Parkinson's disease or Essential Tremor

A minimum of 18 years of age

Willingness to participate in the paradigms described in the protocol

Disqualifiers

Inability to provide full and informed consent

Are not surgical candidates due to co-morbid conditions or pregnancy

Have not undergone an adequate trial of conservative medical management

Have a clinical presentation for which DBS surgery is not indicated

Trial design

Treatments tested in this trial

  • Response Inhibition and Deep Brain Stimulation in Parkinson's disease

Treatment groups

90 Participants
are divided into 2 treatment groups