New Mechanisms of Obesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-22
SponsorYale University
About this trial
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Eligibility criteria
Qualifiers
Age 15 to 22 years
In puberty (girls and boys: Tanner stage III-V);
BMI >85th
Disqualifiers
Pregnancy;
endocrinopathies (e.g., Cushing syndrome);
substance abuse;
medications affecting insulin resistance such as metformin, GLP-1 analogues; -
Trial design
Treatments tested in this trial
- Lactulose Oral Product
Treatment groups
55 Participants
are divided into 2 treatment groupsSponsors and collaborators
Yale University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov