Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement
ConditionHealthy Adult
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-65
SponsorShaklee Corporation
About this trial
The objective of this study is to evaluate nicotinamide adenine dinucleotide (NAD+) in response to a proprietary nutritional supplement in generally healthy adults, compared to placebo.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Males and females, ≥45 to ≤65 years of age
BMI ≥18.5 and <30.0 kg/m2
Ambulatory and currently free of injury or other physical impairment that hinders mobility.
Willing to use personal smart phone with operating system (Android version 12.0 or newer; iOS version 16 or newer).
Disqualifiers
Is currently following, or planning to be on, a weight loss regimen.
Weight loss or gain >4.5 kg.
History of gastrointestinal surgery for weight reducing purposes.
History of an eating disorder (e.g., anorexia nervosa or bulimia nervosa, binge eating) at the discretion of the Clinical Investigator.
Trial design
Design model
Parallel
Treatments tested in this trial
Proprietary Nutritional Supplement
Dietary supplement1000 mg nicotinamide metabolites and plant extracts, taken orally, daily for 60 days
Placebo Supplement
Dietary supplement1000 mg maltodextrin, taken orally, daily for 60 days
Treatment groups
34 Participants
are divided into 2 treatment groupsGroup A: Proprietary nutritional supplementExperimental treatment 1 intervention
Group B: Placebo supplementPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Nicotinamide adenine dinucleotide response in whole blood
Time frame
Baseline to Day 14Secondary outcomes
1
Nicotinamide adenine dinucleotide metabolite responses
Time frame
Baseline to Days 1, 7, 14, and 302
Subjective cognitive function visual analog scales
Participants will rate how they feel on a horizontal line. Lines will be flanked with perceived feelings. Scores range from 0-100, where a higher score indicates increase in that feeling.
Time frame
Baseline to Days 30 and 603
Subjective quality of life questionnaire
Participants will rate how they feel on a Likert scale, where a higher score indicates increase in that feeling.
Time frame
Baseline to Days 30 and 604
Metabolic health markers
Time frame
Baseline to Days 30 and 60Sponsors and contacts
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Source ClinicalTrials.gov