NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
ConditionWorking Memory
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age12-18
SponsorBradley Hospital
About this trial
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23
Eligibility criteria
Qualifiers
Ability to provide assent and have parent provide parental permission
English fluency of the participant and the legal guardian/parent
12-18 years
Parent rating on BRIEF-2 Working Memory: Greater than 1.0 SD above normative mean.
Disqualifiers
Intracranial pathology from a known genetic disorder (e.g., NF1, tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology
History of fainting spells of unknown or undetermined etiology that might constitute seizures
History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy
Any progressive (e.g., neurodegenerative) neurological disorder
Trial design
Treatments tested in this trial
- Active Intermittent Theta Burst Stimulation
- Sham Intermittent Theta Burst Stimulation
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov