Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis
ConditionScarring Alopecia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMontefiore Medical Center
About this trial
The goal of this clinical trial is to evaluate the effectiveness of a non-ablative 1470 nm laser in treating scarring alopecia in adults. The study will also investigate the biochemical molecular pathways involved in laser therapy by analyzing hair follicle gene expression before and after laser treatment.
The main questions it aims to answer are:
1. Does a non-ablative laser work to effectively treat scarring alopecia? 2. What molecular pathways are associated with the laser's effects on hair follicles in scarring alopecia?
Participants with scarring alopecia will:
* Receive 3 laser treatments, spaced 1 month apart (Month 1, Month 2, Month 3), and attend 5 follow-up visits (Month 4, Month 6, Month 9, Month 12 and Month 15) * Have hair follicle samples collected via hair plucking of 10 hairs prior to the start and 1-month post-completion of laser treatments for gene expression analysis of inflammatory and fibrosis pathways implicated in scarring alopecia. Hair samples will be de-identified and kept anonymous. * Fill out questionnaires at each visit * Keep a diary of any side effects from laser treatments
Eligibility criteria
Qualifiers
Healthy males and females, at least 18 years of age at time of informed consent, seeking treatment for scarring alopecia
Subject must be able to read, understand, and voluntarily sign and date an IRB-approved informed consent form
Subjects with biopsy-proven or clinically diagnosed scarring alopecia recorded within the past 6 months. An established clinical diagnosis will be confirmed by a licensed dermatologist as in previously published hair plucking studies (eg. using trichoscopy and a positive pull test). Subjects must have a stable hair loss treatment regimen with a plateau in results for at least 3 months.
Subject agrees to not make any changes to their daily hair treatment regimen or start any medications for hair loss such as minoxidil during the study.
Disqualifiers
Subject does not have capacity to consent to the study
No ethnic or racial group restrictions
Subject does not have scarring alopecia
History of intralesional steroid injections to the scalp in the last 12 months
Trial design
Treatments tested in this trial
- 1470nm non-ablative fractional laser
Treatment groups
5 Participants
are divided into 1 treatment groupSponsors and collaborators
Montefiore Medical Center
Lead sponsor
Sciton
Collaborator
American Society for Laser Surgery and Medicine
Collaborator
Source ClinicalTrials.gov