Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.
Participants aged between 18 and 80 years
Diagnosed with any type of motor neuron disease (MND)
Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3
History of other neurological disorders, such as stroke
Use of ventilatory support
Severe dementia
Chulalongkorn University
Lead sponsor
King Chulalongkorn Memorial Hospital
Collaborator