Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55+
SponsorHebrew SeniorLife

About this trial

This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.

Eligibility criteria

Qualifiers

willing and capable to give informed consent for the participation in the study after it has been thoroughly explained

able and willing to comply with all study requirements

an informed consent form was signed

able to read, write, and communicate in English

Disqualifiers

major psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis

blindness or other disabilities that prevent task performance

contraindications to tES, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, etc.)

the presence of any active dermatological condition, such as eczema, on the scalp a score of 18 or less on the Montreal Cognitive Assessment (MoCA) during the in-person screen

Trial design

Treatments tested in this trial

  • Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)
  • Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)
  • Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)
  • Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)

Treatment groups

144 Participants
are divided into 4 treatment groups

Sponsors and collaborators

Hebrew SeniorLife

Lead sponsor

BrightFocus Foundation

Collaborator

National Institute on Aging (NIA)

Collaborator