Non-invasive Brain Stimulation to Prepare the Patient for Bariatric Surgery (REBAS)

ConditionObesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorMasaryk University

About this trial

Obesity is a chronic metabolic condition characterized by excessive accumulation of body fat, which triggers physiological mechanisms that increase the risk of a wide range of health problems. The most effective treatment for severe obesity is metabolic-bariatric surgery, which can lead to a 15-20% weight reduction, significantly lowering the risks of illness and death. However, the success of this surgery can be threatened by poor eating habits after the procedure. The main goal of this study is to enhance the long-term effectiveness of bariatric surgery by combining it with non-invasive brain stimulation (tDCS) targeting inhibitory centers before the operation. Additionally, the investigators aim to comprehensively monitor patients before and after surgery, focusing on investigating changes in brain function associated with the achieved weight loss.

Eligibility criteria

Qualifiers

Subjects with severe or morbid obesity (determined by BMI > 35 or 40 kg/m2, respectively) eligible for BS treatment in compliance with the current guidelines

Subjects who meet reduced control over eating behavior (disinhibition) criteria in the Eating Habits Questionnaire

Disqualifiers

Subjects unable to provide informed consent and those unable to understand and cooperate with study-related procedures (based on the physician's discretion)

Subjects with a personal history of ischemic heart disease, myocardial infarction, stroke, heart failure, and atrial fibrillation

Subjects who have already undergone BS treatment in the past

Pregnant subjects or subjects that plan on becoming pregnant during the study.

Trial design

Treatments tested in this trial

  • home-based tDCS stimulation
  • home-based tDCS stimulation - sham
  • Bariatric surgery

Treatment groups

65 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Masaryk University

Lead sponsor

St. Anne's University Hospital Brno, Czech Republic

Collaborator