About this trial
Obesity is a chronic metabolic condition characterized by excessive accumulation of body fat, which triggers physiological mechanisms that increase the risk of a wide range of health problems. The most effective treatment for severe obesity is metabolic-bariatric surgery, which can lead to a 15-20% weight reduction, significantly lowering the risks of illness and death. However, the success of this surgery can be threatened by poor eating habits after the procedure. The main goal of this study is to enhance the long-term effectiveness of bariatric surgery by combining it with non-invasive brain stimulation (tDCS) targeting inhibitory centers before the operation. Additionally, the investigators aim to comprehensively monitor patients before and after surgery, focusing on investigating changes in brain function associated with the achieved weight loss.
Eligibility criteria
Qualifiers
Subjects with severe or morbid obesity (determined by BMI > 35 or 40 kg/m2, respectively) eligible for BS treatment in compliance with the current guidelines
Subjects who meet reduced control over eating behavior (disinhibition) criteria in the Eating Habits Questionnaire
Disqualifiers
Subjects unable to provide informed consent and those unable to understand and cooperate with study-related procedures (based on the physician's discretion)
Subjects with a personal history of ischemic heart disease, myocardial infarction, stroke, heart failure, and atrial fibrillation
Subjects who have already undergone BS treatment in the past
Pregnant subjects or subjects that plan on becoming pregnant during the study.
Trial design
Treatments tested in this trial
- home-based tDCS stimulation
- home-based tDCS stimulation - sham
- Bariatric surgery
Treatment groups
Sponsors and collaborators
Masaryk University
Lead sponsor
St. Anne's University Hospital Brno, Czech Republic
Collaborator