About this trial
This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.
Eligibility criteria
Qualifiers
Male or female subject, age 18-55
Competent and willing to sign informed consent
No more than moderately ill
SCID DSM-5 diagnosis of Sz/SzAff
Disqualifiers
Significant neurological illness or history of significant head trauma
Unstable physical illness or significant auditory/visual deficits that might interfer
Contraindication to MRI (e.g. metal implants, claustrophobia, pregnancy)
Contraindications to tDCS including metal implant, pacemaker, history of seizure, traumatic brain injury or stroke
Trial design
Treatments tested in this trial
- transcranial direct current stimulation
- Sham stimulation
Treatment groups
Sponsors and collaborators
Nathan Kline Institute for Psychiatric Research
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Columbia University
Collaborator
Research Foundation for Mental Hygiene, Inc.
Collaborator