Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorNathan Kline Institute for Psychiatric Research

About this trial

This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.

Eligibility criteria

Qualifiers

Male or female subject, age 18-55

Competent and willing to sign informed consent

No more than moderately ill

SCID DSM-5 diagnosis of Sz/SzAff

Disqualifiers

Significant neurological illness or history of significant head trauma

Unstable physical illness or significant auditory/visual deficits that might interfer

Contraindication to MRI (e.g. metal implants, claustrophobia, pregnancy)

Contraindications to tDCS including metal implant, pacemaker, history of seizure, traumatic brain injury or stroke

Trial design

Treatments tested in this trial

  • transcranial direct current stimulation
  • Sham stimulation

Treatment groups

120 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Nathan Kline Institute for Psychiatric Research

Lead sponsor

National Institute of Mental Health (NIMH)

Collaborator

Columbia University

Collaborator

Research Foundation for Mental Hygiene, Inc.

Collaborator