Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorIRCCS Ospedale San Raffaele

About this trial

The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment strategy. The primary objective is to establish whether a new VT ablation based on NIPS inducibility will reduce the risk of VT recurrence compared to antiarrhythmic drug therapy.

Eligibility criteria

Qualifiers

Patients with an implanted ICD (all brands)

Patients who underwent a successful (non-inducibility of any VT) Ventricular Tachycardia Ablation procedure, the "index procedure", supported by EnSite Precision or CARTO 3D mapping systems for the following etiologies: previous MI, myocarditis, ARVD, IDCM.

Induction of monomorphic VT at NIPS 3-7days after a successful index procedure

Age 18 years or more

Disqualifiers

Inducible VT after index procedure

Contraindication to anticoagulants

Presence of thrombi

Presence of Mitral and Aortic prosthetic valve

Trial design

Treatments tested in this trial

  • Re-Do ventricular tachycardia ablation
  • Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)

Treatment groups

51 Participants
are divided into 2 treatment groups

Sponsors and collaborators