Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-85
SponsorUniversity of Wisconsin, Madison
About this trial
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.
Eligibility criteria
Qualifiers
Age 20-85 years
Willing and able to undergo all procedures
Free of any neurological (e.g., epilepsy, stroke, Parkinson's, brain tumors, moderate or severe traumatic brain injury), neuropsychiatric (e.g., schizophrenia, substance abuse, clinical depression), or developmental (e.g., autism, ADHD) or any other medical condition at the discretion of the PI and co-investigators
Age 20-65
Disqualifiers
Contraindication to MRI
Known allergies to common electrode materials
Contraindications for MRI
Known allergies to common electrode materials
Trial design
Treatments tested in this trial
- Functional near-infrared spectroscopy (fNIRS)
- V1 stimulation electrodes
- Magnetic Resonance Imaging (MRI)
- MAGNUS scanner
Treatment groups
55 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Wisconsin, Madison
Lead sponsor
Neuraworx Medical Technologies
Collaborator
Source ClinicalTrials.gov