Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-99
SponsorWashington University School of Medicine

About this trial

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

Eligibility criteria

Qualifiers

Adult patients who present with acute ischemic strokes due to large vessel occlusions

Disqualifiers

<18 years old

patients with presumed chronic large vessel occlusions

NIHSS<6

pre-morbid modified Rankin score (mRS) >2

Trial design

Treatments tested in this trial

  • transcutaneous auricular vagal nerve stimulation
  • Sham transcutaneous vagal nerve stimulation

Treatment groups

65 Participants
are divided into 2 treatment groups