Non-invasive Ventilation Versus High Flow Oxygen
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNiguarda Hospital
About this trial
The purpose of the study is to compare the efficacy of alternating Non Invasive Ventilation NIV and High Flow Oxygen HFO compared to High Flow Oxygen HFO alone on gas exchanges and prognosis in pneumonia-associated acute hypoxemic respiratory failure
Eligibility criteria
Qualifiers
Clinical criteria: fever, cough, purulent sputum, pulmonary examination positive for signs consistent with pneumonia
Laboratory criteria: leukocytosis (White blood cells >10000/mcL) or leukopenia (White blood cells < 4000/mcL), rise of the inflammatory markers
Radiologic criteria: consolidations at Chest X-ray or CT scan
Hypoxemic respiratory failure, based on all the following criteria
Disqualifiers
Age < 18 years
Hypercapnic respiratory failure (pCO2 > 60 mmHg at presentation) such as in Chronic Obstructive Pulmonary Disease
Presence of another cause of hypoxemic respiratory failure - e.g. pulmonary embolism, acute respiratory distress syndrome (ARDS), pulmonary oedema
Hemodynamic instability with necessity for use of inotropes and/or vasopressors
Trial design
Treatments tested in this trial
- High Flow Oxygen nasal cannula
- Noninvasive ventilation
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov