Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis

ConditionBronchiolitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-2
SponsorMontefiore Medical Center

About this trial

This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy (including intubation) when compared to using a standard mode of non-invasive ventilation. Neurally-Adjusted Ventilatory Assistance (NAVA) has been shown to result in greater synchrony then the standard mode of non-invasive ventilation. The study team hypothesizes that this improved synchrony can result in important clinical improvements when NAVA is used to treat children with bronchiolitis.

Eligibility criteria

Qualifiers

Patients under the age of two years old with a diagnosis of bronchiolitis presenting to the pediatric ICU

Patient's provider believes there is equipoise between the use of NAVA or conventional non-invasive ventilation for the patient

Disqualifiers

Patients unable to utilize a nasogastric tube

Patients with a diagnosis of chronic lung disease, cyanotic heart lesions, or congestive heart failure

Patients with hypotonia

Patients likely to require imminent intubation: >0.60 Fraction of Inspired Oxygen (FiO2); Carbon Dioxide (CO2) > 60, frequent apneas, clinician determines patient unlikely to tolerate non-invasive modality)

Trial design

Treatments tested in this trial

  • Standard Non-Invasive Mechanical Servo Ventilation
  • Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Mechanical Servo Ventilation

Treatment groups

130 Participants
are divided into 2 treatment groups

Sponsors and collaborators