Noncontrast CT-Based Deep Learning for Predicting Hematoma Expansion Risk in Patients with Spontaneous Intracerebral Hemorrhage

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorQiang Yu

About this trial

Hematoma expansion is an independent predictor of poor prognosis and early neurological deterioration in patients with spontaneous intracerebral hemorrhage. Early identification of high-risk patients and timely targeted medical interventions may provide a crucial opportunity to limit hematoma growth and improve neurological outcomes. This study aims to develop an end-to-end deep learning model based on noncontrast computed tomography images to predict the risk of hematoma expansion in patients with spontaneous intracerebral hemorrhage. This model could serve as a valuable risk stratification tool for patients with hematoma expansion, facilitating targeted treatment and providing clinicians with streamlined decision-making support in emergency situations.

Eligibility criteria

Qualifiers

Primary, spontaneous (non-traumatic) intracerebral hemorrhage (ICH).

Age ≥ 18 years.

Baseline CT performed within 24 hours of ICH symptom onset or last seen well (LSW).

Follow-up CT within 72 hours.

Disqualifiers

Secondary ICH caused by trauma, vascular anomalies (e.g., aneurysm, cavernous angioma, arteriovenous malformation), brain tumor, or hemorrhagic transformation in brain infarction.

Primary intraventricular hemorrhage (IVH).

Surgical treatment with external ventricular drain placement or craniotomy.

Obvious artifacts observed in CT images.

Trial design

Treatments tested in this trial

  • Observational study, no interventions involved

Treatment groups

2,000 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Qiang Yu

Lead sponsor

First Affiliated Hospital of Chongqing Medical University

Sponsor institution

Xiangya Hospital of Central South University

Collaborator

The First Affiliated Hospital with Nanjing Medical University

Collaborator

Southwest Hospital, China

Collaborator

Liuzhou Workers' Hospital

Collaborator