About this trial
The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may change the foundation for how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.
Eligibility criteria
Qualifiers
None
Disqualifiers
previous diagnosis of Intellectual Disability;
known uncorrectable visual impairment;
documented hearing impairment greater than or equal to a 25 dB loss;
medical contraindication to MRI procedures (e.g., metal devices);
Trial design
Treatments tested in this trial
- Sham intervention
- RLN real non-invasive brain stimulation intervention
- RLN and CCN real non-invasive brain stimulation intervention
Treatment groups
Sponsors and collaborators
Vanderbilt University
Lead sponsor
National Institutes of Health (NIH)
Collaborator