This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center. Component 1 (active upon IRB approval) validates Brain4Care (B4C) extensometry-derived noninvasive cerebral autoregulation (CA) indices against invasive ICP-derived equivalents in aSAH patients with open external ventricular drains (EVDs), and characterizes the prospective natural history of multi-modal CA parameter evolution through the delayed cerebral ischemia (DCI) window (admission through Day 14). Component 2 (activated upon PI readiness declaration) assesses the within-subject effect of cervical sympathetic block (CSB) and transcutaneous auricular vagal nerve stimulation (taVNS) on CA parameters in enrolled aSAH patients.
Age 18 years or older
Primary diagnosis of aneurysmal subarachnoid hemorrhage (aSAH), confirmed by imaging
Admitted to the NSICU at Clements University Hospital, UT Southwestern Medical Center
Informed consent obtained from subject or legally authorized representative (as defined under Texas Health and Safety Code Section 166.039)
Age younger than 18 years
Prisoner status
Primary NSICU admission diagnosis other than aSAH
Active declination by subject or legally authorized representative